AustralieFrV1, Main, Exploration, bibRecord, 003883

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research

Identifieur interne : 003883 ( Main/Exploration ); précédent : 003882; suivant : 003884

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research

Auteurs : Sid E. O Ryant [États-Unis] ; Veer Gupta [Australie] ; Kim Henriksen [Danemark] ; Melissa Edwards [États-Unis] ; Andreas Jeromin [États-Unis] ; Simone Lista ; Chantal Bazenet [Royaume-Uni] ; Holly Soares [États-Unis] ; Simon Lovestone [Royaume-Uni] ; Harald Hampel [France] ; Thomas Montine [États-Unis] ; Kaj Blennow [Suède] ; Tatiana Foroud [États-Unis] ; Maria Carrillo [États-Unis] ; Neill Graff-Radford [États-Unis] ; Christoph Laske [Allemagne] ; Monique Breteler [Allemagne] ; Leslie Shaw [États-Unis] ; John Q. Trojanowski [États-Unis] ; Nicole Schupf [États-Unis] ; Robert A. Rissman [États-Unis] ; Anne M. Fagan [États-Unis] ; Pankaj Oberoi [États-Unis] ; Robert Umek [États-Unis] ; Michael W. Weiner [États-Unis] ; Paula Grammas [États-Unis] ; Holly Posner [États-Unis] ; Ralph Martins [Australie]

Source :

Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5260 ] ; 2014.

RBID : PMC:4414664

Descripteurs français

KwdFr :
- Humains, Maladie d'Alzheimer (), Maladie d'Alzheimer (sang), Marqueurs biologiques (), Marqueurs biologiques (sang), Recommandations comme sujet (normes).
MESH :
- normes : Recommandations comme sujet.
- sang : Maladie d'Alzheimer, Marqueurs biologiques.
- Humains, Maladie d'Alzheimer, Marqueurs biologiques.

English descriptors

KwdEn :
- Alzheimer Disease (blood), Alzheimer Disease (cerebrospinal fluid), Biomarkers (blood), Biomarkers (cerebrospinal fluid), Guidelines as Topic (standards), Humans.
MESH :
- chemical , blood : Biomarkers.
- blood : Alzheimer Disease.
- cerebrospinal fluid : Alzheimer Disease, Biomarkers.
- standards : Guidelines as Topic.
- Humans.

Abstract

The lack of readily available biomarkers is a significant hindrance towards progressing to effective therapeutic and preventative strategies for Alzheimer’s disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field in order to foster cross-validation across cohorts and laboratories.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414664

DOI: 10.1016/j.jalz.2014.08.099
PubMed: 25282381
PubMed Central: 4414664

Affiliations:

Le document en format XML

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<author><name sortKey="Jeromin, Andreas" sort="Jeromin, Andreas" uniqKey="Jeromin A" first="Andreas" last="Jeromin">Andreas Jeromin</name>
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</affiliation>
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</affiliation>
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</placeName>
</affiliation>
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<wicri:regionArea>Bristol-Myers Squibb, Wallingford, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
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<author><name sortKey="Montine, Thomas" sort="Montine, Thomas" uniqKey="Montine T" first="Thomas" last="Montine">Thomas Montine</name>
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</placeName>
<orgName type="university">Université de Washington</orgName>
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</author>
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<author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Carrillo, Maria" sort="Carrillo, Maria" uniqKey="Carrillo M" first="Maria" last="Carrillo">Maria Carrillo</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Alzheimer’s Association, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Graff Radford, Neill" sort="Graff Radford, Neill" uniqKey="Graff Radford N" first="Neill" last="Graff-Radford">Neill Graff-Radford</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Laske, Christoph" sort="Laske, Christoph" uniqKey="Laske C" first="Christoph" last="Laske">Christoph Laske</name>
<affiliation wicri:level="3"><nlm:aff id="A15">Section for Dementia Research, Hertie-Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section for Dementia Research, Hertie-Institute of Clinical Brain Research, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique" sort="Breteler, Monique" uniqKey="Breteler M" first="Monique" last="Breteler">Monique Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A16">Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany & German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Shaw, Leslie" sort="Shaw, Leslie" uniqKey="Shaw L" first="Leslie" last="Shaw">Leslie Shaw</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name>
<affiliation wicri:level="4"><nlm:aff id="A18">Department of Epidemiology, Joseph P Mailman School of Public Health, Columbia University, New York, NY, USA</nlm:aff>
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<wicri:regionArea>Department of Epidemiology, Joseph P Mailman School of Public Health, Columbia University, New York, NY</wicri:regionArea>
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<settlement type="city">New York</settlement>
</placeName>
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<affiliation wicri:level="4"><nlm:aff id="A20">Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, St. Louis, MO</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Oberoi, Pankaj" sort="Oberoi, Pankaj" uniqKey="Oberoi P" first="Pankaj" last="Oberoi">Pankaj Oberoi</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Meso Scale Discovery, Rockville, MD, USA</nlm:aff>
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<wicri:regionArea>Meso Scale Discovery, Rockville, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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</affiliation>
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<author><name sortKey="Umek, Robert" sort="Umek, Robert" uniqKey="Umek R" first="Robert" last="Umek">Robert Umek</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Meso Scale Discovery, Rockville, MD, USA</nlm:aff>
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<author><name sortKey="Weiner, Michael W" sort="Weiner, Michael W" uniqKey="Weiner M" first="Michael W." last="Weiner">Michael W. Weiner</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Department of Medicine, Radiology and Psychiatry, University of California, San Francisco, San Francisco, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Grammas, Paula" sort="Grammas, Paula" uniqKey="Grammas P" first="Paula" last="Grammas">Paula Grammas</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Texas Tech University Health Science Center, Garrison Institute on Aging, Lubbock, TX, USA</nlm:aff>
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<author><name sortKey="Posner, Holly" sort="Posner, Holly" uniqKey="Posner H" first="Holly" last="Posner">Holly Posner</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Pfizer Inc., New York, NY, USA</nlm:aff>
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<wicri:regionArea>Pfizer Inc., New York, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martins, Ralph" sort="Martins, Ralph" uniqKey="Martins R" first="Ralph" last="Martins">Ralph Martins</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Centre of Excellence for Alzheimer’s Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre of Excellence for Alzheimer’s Disease Research & Care, School of Medical Sciences, Edith Cowan University, Joondalup, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title>
<idno type="ISSN">1552-5260</idno>
<idno type="eISSN">1552-5279</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (blood)</term>
<term>Alzheimer Disease (cerebrospinal fluid)</term>
<term>Biomarkers (blood)</term>
<term>Biomarkers (cerebrospinal fluid)</term>
<term>Guidelines as Topic (standards)</term>
<term>Humans</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term>
<term>Maladie d'Alzheimer ()</term>
<term>Maladie d'Alzheimer (sang)</term>
<term>Marqueurs biologiques ()</term>
<term>Marqueurs biologiques (sang)</term>
<term>Recommandations comme sujet (normes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Alzheimer Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Alzheimer Disease</term>
<term>Biomarkers</term>
</keywords>
<keywords scheme="MESH" qualifier="normes" xml:lang="fr"><term>Recommandations comme sujet</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Maladie d'Alzheimer</term>
<term>Marqueurs biologiques</term>
</keywords>
<keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Guidelines as Topic</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Humains</term>
<term>Maladie d'Alzheimer</term>
<term>Marqueurs biologiques</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The lack of readily available biomarkers is a significant hindrance towards progressing to effective therapeutic and preventative strategies for Alzheimer’s disease (AD). Blood-based biomarkers have potential to overcome access and cost barriers and greatly facilitate advanced neuroimaging and cerebrospinal fluid biomarker approaches. Despite the fact that preanalytical processing is the largest source of variability in laboratory testing, there are no currently available standardized preanalytical guidelines. The current international working group provides the initial starting point for such guidelines for standardized operating procedures (SOPs). It is anticipated that these guidelines will be updated as additional research findings become available. The statement provides (1) a synopsis of selected preanalytical methods utilized in many international AD cohort studies, (2) initial draft guidelines/SOPs for preanalytical methods, and (3) a list of required methodological information and protocols to be made available for publications in the field in order to foster cross-validation across cohorts and laboratories.</p>
</div>
</front>
</TEI>
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Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research

Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer’s disease research

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	Serveur d'exploration sur les relations entre la France et l'Australie
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